The Charcot Marie Tooth Neuropathy Score (CMTNS) (version 2) is “a validated measure of length-dependent axonal and demyelinating CMT disability and can be investigated as an endpoint for longitudinal studies and clinical trials of CMT.” It was designed for CMT1A and is best suited to moderate-severe cases, but it can and has been used to assess the level of impairment for all kinds of CMT. There’s also the Rasch-modified CMTNS (CMTNS-R). Along with the Ambulation Index (AI) the CMTNS can predict orthotic needs.
The CMT Exam Score (CMTES) and Rasch-modified CMTES (CMTES-R) is the clinical component of the CMTNS. It is a validated composite scale for CMT with a score ranging from 0 (normal; no impairment) to 28 (highest level of impairment). Read More›
The Charcot-Marie-Tooth Functional Outcome Measure (CMT-FOM) is a new performance-based measure assessing the functional ability of adults with CMT.
The Overall Neuropathy Limitations Scale (ONLS) is a modification of the Overall Disability Sum Score (ODSS), which assesses arm and leg disability. “CMTNS and ONLS are considered the main clinical scales for impairment and disability, respectively, in CMT1A disease.”
Gait Assessment categorizes walking gait as “Normal-like” (NL), “Foot-Drop” (FD), or “Foot-Drop and Push-off Deficit” (FD&POD).