This is interesting — some researchers looked at CMT1A impairment of hand strength, mobility, and general functioning for its impact on health-related quality of life (HRQoL).
Even though the measurable electrophysiological impact of CMT1A is high, the subjective level of experienced disability is pretty low, given the ways you can learn to compensate. So the study showed there wasn’t much impact on quality of life, even in terms of depression and fatigue:
The impact of CMT on well-being was assessed with the Medical Outcomes Study Short Form 36 (SF-36), Beck Depression Inventory, and the Fatigue Severity Scale.
I imagine the results might be different for someone who lost a particular skill or who really wanted to be doing something that CMT made more difficult if not impossible.
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